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Synthesis and Screening of a DNA-Encoded Library of Non-Peptidic Macrocycles.
Koesema E, Roy A, Paciaroni NG, Coito C, Tokmina-Roszyk M, Kodadek T. Koesema E, et al. Among authors: paciaroni ng. Angew Chem Int Ed Engl. 2022 Apr 25;61(18):e202116999. doi: 10.1002/anie.202116999. Epub 2022 Mar 2. Angew Chem Int Ed Engl. 2022. PMID: 35192245 Free PMC article.
First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival.
Guijarro MV, Kellish PC, Dib PE, Paciaroni NG, Nawab A, Andring J, Kulemina L, Borrero NV, Modenutti C, Feely M, Nasri E, Seifert RP, Luo X, Bennett RL, Shabashvili D, Licht JD, McKenna R, Roitberg A, Huigens RW 3rd, Kaye FJ, Zajac-Kaye M. Guijarro MV, et al. Among authors: paciaroni ng. JCI Insight. 2023 Apr 25;8(10):e158798. doi: 10.1172/jci.insight.158798. JCI Insight. 2023. PMID: 37097751 Free PMC article.